First author Dr. Olivia Bracken (UCL Department of Ageing, Rheumatology and Regenerative Medicine) said: "Our findings reveal a natural pathway that limits harmful immune cell expansion and helps calm inflammation more quickly.

“Targeting this mechanism could lead to safer treatments that restore immune balance without suppressing overall immunity. With chronic inflammation ranked as a major global health threat, this discovery opens a promising avenue for new therapies.”

  • Donn@slrpnk.net
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    2 hours ago

    Blocking sEH increased epoxy-oxylipin levels, helped pain resolve more quickly, and sharply reduced the number of intermediate monocytes found in both the blood and tissue. These immune cells have been linked to persistent inflammation and the progression of inflammatory disease.

    redness/swelling aren’t the only markers of inflammation in this context, as the cells that kick off the response do more harm than good when they wear out their welcome.

    monocytes are white blood cells that develop in bone marrow. i’m curious/interested in whether the same treatment affects mast cells that develop in connective tissue

    • sartalon@lemmy.world
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      2 hours ago

      They spent several paragraphs talking about how the test was setup but then said, well, we didn’t see anything, so it must be reacting at a deeper level.

      Other than an apparent reduction in pain and a reduction in the number of monocytes, there was no mechanism to make the claim that they could switch off inflammation.

      I was hoping for a little more than that.

      The best claim the article should have made was they found a way to reduce monocytes, which have been shown to be associated with the body’s inflammation response

      They still don’t even understand how the monocyte side of the equation really works either.

      I don’t disagree that this should lead to more testing, and I also hope that it might lead to better treatments but that title sits firmly in the “clickbait” arena for me.