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Cake day: November 28th, 2025

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  • I can’t tell if I’m dumb, but directly from your linked review, under “Epidemiology” (Bolding is mine)

    Twin and family studies have demonstrated strong familial inheritance patterns for SUDs (Prom-Wormley, Ebejer, Dick, & Bowers, 2017). Heritability (h2) estimates across SUDs vary, but broadly suggest that genetic influences account for approximately 50% of the risk. Quantitative genetic studies have also suggested that, in addition to the presence of substance-specific influences for SUDs – with nicotine and opiates showing the most evidence of substance-specific genetic factors (Kendler, Myers, & Prescott,2007; Tsuang et al., 1998) – there are heritable factors that contribute to SUDs more broadly (Kendler et al., 2007; Kendler, Prescott, Myers, & Neale, 2003).

    Alcohol use disorder

    Heritability estimates for AUD range from ∼0.50 to 0.64 (Heath et al., 1997; Kendler, 2001), with a recent meta-analysis reporting h2 of ∼0.50 (Verhulst, Neale, & Kendler, 2015). Heritability estimates for AUD diagnosis tend to be slightly higher than for other alcohol-related traits, such as alcohol use initiation (h2 = 0.30–0.40; Koopmans, Slutske, Van Baal, & Boomsma, 1999) and alcohol use frequency (h2 = 0.37–0.47; Viken, Kaprio, Koskenvuo, & Rose, 1999), which is consistent with prior twin studies suggesting that environmental influences may have a more pronounced impact on initiation, while genetic factors are more influential in progression to heavier use and substance-related problems

    (Kendler, Karkowski, Neale, & Prescott, 2000).

    Edit: reread your first comment. I see what you’re saying. I think its a silly distinction, but I could see your argument. Leaving this for posterity