You’d think these are all just thought experiments, but nature and humanity really said “fuck Point Nemo”:

The oceanic pole of inaccessibility, also known as Point Nemo, (…) is the place in the ocean that is farthest from land. (…)

The area is so remote that, since no regular marine or air traffic routes are within 400 kilometres (250 mi), sometimes the closest human beings are astronauts aboard the International Space Station when it passes overhead.[23][24]

(…)

Point Nemo is relatively lifeless; its location within the South Pacific Gyre blocks nutrients from reaching the area, and being so far from land it gets little nutrient run-off from coastal waters.[23]