Topical Diclofenac, an Efficacious Treatment for Osteoarthritis: A Narrative Review
pmc.ncbi.nlm.nih.gov
Multiple head-to-head trials have demonstrated that topical nonsteroidal anti-inflammatory drugs (NSAIDs), including topical diclofenac, provide at least equivalent analgesia, improvement in physical function, and reduction of stiffness compared ...

“inflammation is now understood to be a key mediator of OA that contributes to cartilage loss and progressive degeneration of affected joints… OA is no longer considered a noninflammatory arthritis or a ‘wear and tear’ disease”

I heretofore thought age-related cartilage loss was the cause of osteoarthritis and inflammation. Turns out it’s the other way around: the inflammation degrades cartilage. Okay, no more slogging through joint pains for me, regardless of how small.

Edit: added a phrase for clarity

  • Tollana1234567@lemmy.todayEnglish
    2·
    3 days ago

    i think prednisone’s side effect is more apparent if you are on higher doses for longer periods of time, 80-100mg per day. i took it for 2 weeks for severe atopic dermatitis, dint cause any symptoms, since it was a taper too.

    for RA, you should request biologic medications, theres a couple out for them already. Likewise with people with psoriasis/psoriatic arthiritis.

    • Reyali@lemmy.worldEnglish
      2·
      2 days ago

      I started on biologics after diagnosis and they didn’t work for me. I am on a daily JAK inhibitor and a twice-daily NSAID and that has my pain controlled. The current swelling is something new, and is not painful.

      The long-term prednisone use was to help me manage the pain while seeing if a biologic would work. It helped, but I still had to take ~15 mg of prednisone a day or I was in debilitating pain.